Sanofi's genetic disorder drug shows mixed results in late-stage trials

By Bhanvi Satija

Reuters

LONDON, Feb 2 (Reuters) - French drugmaker Sanofi said on Monday that its experimental genetic disorder treatment showed promise in a late-stage study of patients with ​a type of Gaucher disease, but failed to meet the main goal in ‌a separate trial.

The oral drug, venglustat, was being tested in patients with Fabry disease and type 3 Gaucher disease. Both ‌inherited conditions are caused by enzyme deficiencies that lead to the accumulation of toxic substances in the body.

Previous failures in trials of patients with Parkinson's disease and a type of acute kidney disease have prompted Sanofi to prioritize testing the drug in rare genetic disorders, where its mechanism of ⁠blocking the buildup of harmful fatty ‌molecules has yielded promising early-stage results.

Analysts have not projected future sales for venglustat as market expectations for its success remain low.

Sanofi is banking on ‍its late-stage pipeline and recent acquisitions to help drive sales growth in the next decade, after the top-selling eczema and asthma drug Dupixent it shares with Regeneron loses exclusivity.

Sanofi's bet could pay off if venglustat is ​eventually approved, making it the first such drug to target neurological symptoms and giving patients ‌an oral dosing option.

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"A daily pill could make a serious difference for Gaucher patients facing neurological challenges," said Sanofi research chief Houman Ashrafian.

But the drug's path to regulatory approval looks murky, especially for Fabry disease. Ashrafian said data from the Fabry disease study was still being analysed, while the company said it would work with global regulators to determine next steps.

STUDY DETAILS

The drug ⁠showed superior improvements in neurological symptoms such as speech ​and limb coordination for type 3 Gaucher disease patients, ​compared to those who received enzyme replacement therapy. It also demonstrated statistically significant improvements on three of four secondary goals of that study.

In patients with Fabry ‍disease, venglustat helped reduce ⁠neuropathic and abdominal pain, but not enough to declare statistical success. Sanofi suggested that may be due to a large placebo effect. The company said it helped reduce levels ⁠of plasma lyso-GL-3 in patients, which is an indicator of accumulated harmful fat molecules.

Sanofi already sells Fabrazyme, an enzyme‑replacement ‌therapy for Fabry disease, and markets Cerezyme and the oral drug Cerdelga for ‌Gaucher disease.

(Reporting by Bhanvi SatijaEditing by Bill Berkrot)

Sanofi's genetic disorder drug shows mixed results in late-stage trials

By Bhanvi Satija LONDON, Feb 2 (Reuters) - French drugmaker Sanofi said on Monday that its experimental geneti...
Factbox-Which are the main parties in Thailand's election and what are their policies?

Feb 2 (Reuters) - Thailand is holding a general election on February 8 with three parties expected to dominate the contest to decide which will lead the Southeast Asian country's next government.

Reuters Supporters of the Bhumjaithai Party react during a general election campaign rally ahead of the February 8 election in Bangkok, Thailand, January 30, 2026. REUTERS/Athit Perawongmetha Supporters of the Bhumjaithai Party react during a general election campaign rally ahead of the February 8 election in Bangkok, Thailand, January 30, 2026. REUTERS/Athit Perawongmetha

Thailand's Bhumjaithai party campaign ahead of Thailand's general election in Bangkok

Following are details and key policy pledges of the main parties running in the election.

BHUMJAITHAI PARTY

Led by incumbent Prime Minister Anutin Charnvirakul, Bhumjaithai formed the last government in September after moving in swiftly ​to dismantle the Pheu Thai-led coalition following a court's sacking of then premier Paetongtarn Shinawatra. Bhumjaithai was not a contender in the 2023 and 2019 elections, taking 71 and 51 seats respectively, though enough ‌to earn spots in the coalition governments.

Bhumjaithai has brought in technocrats and will hope to benefit from its incumbency and defections from other parties to boost its share of the vote. It will likely need to form an alliance to lead the next government.

Key policies:

- Phase two ‌of a co-payment subsidy scheme that in stage one covered half of the cost of selected food and consumer goods

- Boost growth to above 3% through a "10-Plus Plan", including support for low-income earners, better income and care for seniors; community-based products; free education with job pathways, support for small businesses

- Construct border walls to prevent smuggling of illicit goods, illegal labour, proliferation of "grey" businesses

- Introduce volunteer soldiers posts with monthly salaries; create 100,000 jobs in a "One Village, One Volunteer Nurse" scheme

- Barter trade for major state purchases such as fighter jets and submarines, paid for with Thai farm goods

- National disaster fund to support co-pay insurance for 29.5 million households

- Cheap loans for buying electric motorcycles

- Boost small businesses through state procurement, ⁠cheap loans, credit guarantees, new market access

- Promote green economy initiatives, community solar cells, ‌and cap household electricity bills

PHEU THAI PARTY

Pheu Thai and its predecessors have dominated Thai politics for the past quarter-century through huge electoral war chests and populist policies that won massive working class support and loyalty.

Founded by divisive, currently jailed billionaire Thaksin Shinawatra, the party has powerful enemies in the royalist establishment. Six premiers from or allied with the Shinawatra ‍family have been removed by military coups and court rulings.

The 2023 election was the first since 2001 where Thaksin-backed parties did not win the most votes. Pheu Thai's support has been challenged of late following Paetongtarn's removal and its failure to fully implement its signature "digital wallet" handout programme.

Key policies:

- "Millionaire-maker" campaign that award nine daily prizes of 1 million baht ($31,556) each, targeting tax filers, seniors over 60, farmers, volunteers and buyers of goods and services

- Top-up incomes for those with annual earnings below 36,000 baht ($1,163)

- For rice, ​cassava, rubber and corn, set market price targets; guarantee farmers at least 30% profit in first year

- Coupons for up to 250 kg (551 pounds) of fertiliser and 150 kg of seeds per household

- Suspend principal and interest ‌for three years on loans up to 500,000 baht for farmers

- Convert land documents to full land title deeds for 33 million rai (about 13 acres)

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- 500,000 baht ($16,150) in seed funding per startup, plus five‑year tax exemptions

- Add mental health services as a core benefit under a 30 baht universal healthcare scheme

- Establish a national credit guarantee agency to support small businesses

- Programme aimed at developing 20 million high‑skilled workers

- Affordable housing with low instalments and no downpayment for qualified first-time buyers

- Flat 20 baht rate for all trips on electric trains; two‑year motorcycle tax exemption for delivery riders

- Relief for holders of non-performing loans below specified thresholds; small loans from state banks to repay informal debt

PEOPLE'S PARTY

People's Party is the third incarnation of the progressive movement after its two popular predecessors were dissolved by courts, including Move Forward, which won most votes in the 2023 election but was blocked from forming a government by a Senate ⁠hand-picked by the military.

Surveys consistently show People's Party is Thailand's most popular party, suggesting it still has strong backing among young ​and urban Thais for its liberal policies and institutional reform agenda.

Though it is a contender to win, its efforts to form a government ​could again encounter turbulence, with long-term reforms it has previously pledged and some of its current manifesto posing a challenge to the interests of conservatives, powerful families and business groups with far-reaching political influence.

Key policies:

- Replace military conscription with a fully voluntary military with enlistment contracts of 4-8 years; reduce number of generals; improve welfare for lower-ranking soldiers

- Government guarantees on new ‍loans for small businesses and upgrades to national credit database

- ⁠Tighten screening for company registrations to tackle illicit businesses; crackdown on nominee structures and grey capital; increase penalties and shorten court processes

- Develop a southern port link system to cut logistics costs and strengthen southern economy

- Single transport ticket capping trip prices on urban rail, buses and ferries

- National single-wage formula adjusted annually based on living costs and economic conditions

- Provide 1,000 baht co-payment top-up for 12 million people

- Subsidise ⁠training for new skills; provide courses linked to labour market needs

- Raise VAT to 8% by 2028 and 10% by 2030, with compensation for low‑income households

- Reform to police to prevent buying/selling of police positions

- Limit working hours to five days or 40 hours per week, ‌with overtime pay required beyond

- Implement menstrual leave up to 3 days per month and annual compassionate/care leave up to 15 days

- Establish a 10 billion baht annual fund to buy and ‌absorb surplus farm produce before prices fall

($1 = 31.6900 baht)

(Compiled by Orathai Sriring and Martin Petty; Editing by Raju Gopalakrishnan)

Factbox-Which are the main parties in Thailand's election and what are their policies?

Feb 2 (Reuters) - Thailand is holding a general election on February 8 with three parties expected to dominate the contes...
Japan PM Takaichi's party poised for landslide victory, poll shows

By Leika Kihara

TOKYO, Feb 2 (Reuters) - Japanese Prime Minister Sanae Takaichi's party is likely to score a landslide victory in next week's lower house election, a survey by the Asahi newspaper showed, heightening the chance the country will continue to pursue big ​spending and tax cuts.

A strong showing in Sunday's election would solidify Takaichi's grip on her party and give a mandate for her ‌expansionary fiscal policy, which could heighten concerns about Japan's finances and push bond yields higher.

"Implementing expansionary fiscal policy at a time the economy is at near full employment would heighten inflationary ‌pressure" and weaken the yen, said Ryutaro Kono, chief Japan economist at BNP Paribas.

"The Bank of Japan may be forced to accelerate the pace of interest rate hikes to combat the weak yen and inflationary pressures from expansionary fiscal policy," he said.

Takaichi's Liberal Democratic Party is likely to well exceed a majority of 233 seats out of 465 seats up for grabs in the lower house, according to Asahi's poll released on Sunday. That would be an increase from 198 seats ⁠now.

Together with LDP's coalition partner, the Japan Innovation ‌Party or Ishin, the ruling alliance will likely reach 300 seats, the poll showed.

The largest opposition party, the Centrist Reform Alliance, is struggling and could lose half its 167 seats, the Asahi said.

Super-long Japanese government bond yields, which are sensitive to ‍fiscal risks, rose on Monday as investors priced in the chance Takaichi will push through her "proactive" fiscal policy focused on bigger spending and tax cuts.

The yen wobbled after Takaichi's weekend comments in which she talked up the benefits of a weaker currency were seen as condoning its declines and running counter to efforts by Japanese authorities to ​prop it up.

"People say the weak yen is bad right now, but for export industries, it's a major opportunity," Takaichi said on Saturday, adding ‌that the currency's decline would boost the value of Japan's huge foreign reserves.

A government spokesperson said on Monday Takaichi was not highlighting the benefits of a weak yen, and instead stressing the need to create an economic structure resilient to currency fluctuations.

A weak yen has been a source of headache for Japanese policymakers as it pushes up import costs and broader inflation.

FISCAL RISK WORRIES MAY BE OVERBLOWN

Takaichi's ruling coalition currently holds a slim majority in the powerful lower house but has a minority in the upper house. The premier dissolved parliament last month and called a snap election on February 8 seeking ⁠a mandate for her push to reflate the economy with expansionary fiscal policy.

Japan suffered ​a broad market rout last month after Takaichi pledged to suspend an 8% levy on ​food sales for two years, reviving investor concerns about fiscal discipline in a country with public debt more than twice the size of its economy.

Most parties have also called for a suspension or a cut to the consumption tax to cushion ‍the blow to households from rising living ⁠costs.

Some analysts say a strong LDP win could actually prevent Japan from resorting to extreme tax cuts or spending plans proposed by some opposition parties.

The LDP remains vague on how soon the tax suspension could be put in place, saying only that the timing should be ⁠decided in a meeting of ruling and opposition parties.

In its campaign pledge, the LDP clearly commits to reducing Japan's debt-to-GDP ratio, and pursuing expenditure and revenue reforms, said Takeshi Yamaguchi, ‌chief Japan economist at Morgan Stanley MUFG Securities.

"Our view that excessive concern over Japan's fiscal position is unnecessary remains unchanged," he ‌said.

(Reporting by Leika Kihara; Editing by Cynthia Osterman, Sonali Paul and Stephen Coates)

Japan PM Takaichi's party poised for landslide victory, poll shows

By Leika Kihara TOKYO, Feb 2 (Reuters) - Japanese Prime Minister Sanae Takaichi's party is likely to score a...
Wembanyama fuels early surge in late start as Spurs overcome travel woes to beat Magic

SAN ANTONIO (AP) — Victor Wembanyama had 25 points, eight rebounds and five blocks and San Antonio beat the Orlando Magic 112-103 on Sunday night in a game that started five hours late because of the Spurs' travel woes.

Associated Press San Antonio Spurs forward Victor Wembanyama (1) scores over Orlando Magic guard Desmond Bane (3) during the first half of an NBA basketball game in San Antonio, Sunday, Feb. 1, 2026. (AP Photo/Eric Gay) San Antonio Spurs forward Victor Wembanyama (1) scores against the Orlando Magic during the second half of an NBA basketball game in San Antonio, Sunday, Feb. 1, 2026. (AP Photo/Eric Gay) Orlando Magic guard Desmond Bane (3) shoots over San Antonio Spurs forward Victor Wembanyama (1) during the first half of an NBA basketball game in San Antonio, Sunday, Feb. 1, 2026. (AP Photo/Eric Gay) Orlando Magic forward Paolo Banchero (5) jumps to save a loose ball from going out of bounds during the first half of an NBA basketball game against the San Antonio Spurs in San Antonio, Sunday, Feb. 1, 2026. (AP Photo/Eric Gay) San Antonio Spurs forward Victor Wembanyama (1) drives against Orlando Magic center Wendell Carter Jr. (34) during the second half of an NBA basketball game in San Antonio, Sunday, Feb. 1, 2026. (AP Photo/Eric Gay)

Magic Spurs Basketball

The Spurs were scheduled to leave Charlotte following a111-106 lossSaturday, but had to stay overnight because of thestorm that dropped nearly a foot of snow. The team then had a mechanical issue on its flight.

Devin Vassell added 16 points for San Antonio. Dylan Harper had 15 points, and De'Aaron Fox had 14 points and 10 assists.

Desmond Bane scored 25 points for Orlando, and Paolo Banchero had 19 points and 10 rebounds. Orlando had won two in a row.

The Magic had been in San Antonio since Saturday after a 130-120 home victory over Toronto. The Spurs weren't so lucky.

The game was scheduled to start at 3 p.m. but was pushed back to 6 p.m. and then 8 p.m. as the Spurs returned home nearly 24 hours later than planned.

The delayed start did not hinder the Spurs as they made their first three shots and seven of their first eight in building a double-digit lead five minutes in, Wembanyama made his first two attempts, forcing his way past Wendell Carter Jr. in the lane for a finger-roll layup and a two-handed slam.

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Wembanyama was cleared to play a half hour before tipoff after being questionable due to left calf soreness.

San Antonio guard Stephon Castle missed the game with left adductor tightness.

Magic: At Oklahoma City on Tuesday night.

Spurs: Host Oklahoma City on Wednesday night.

AP NBA:https://apnews.com/hub/NBA

Wembanyama fuels early surge in late start as Spurs overcome travel woes to beat Magic

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Chris Kreider scores 2 goals, Ducks beat slumping Golden Knights 4-3 to sweep season series

ANAHEIM, Calif. (AP) — Chris Kreider scored two goals, Lukas Dostal made 27 saves and the Anaheim Ducks swept their three-game season series with the Vegas Golden Knights with a 4-3 victory on Sunday night.

Associated Press Vegas Golden Knights right wing Jonas Rondbjerg, right, falls after being hit by Anaheim Ducks defenseman Jacob Trouba during the second period of an NHL hockey game Sunday, Feb. 1, 2026, in Anaheim, Calif. (AP Photo/Mark J. Terrill) Anaheim Ducks center Ryan Poehling celebrates his assist on a goal by left wing Chris Kreider during the first period of an NHL hockey game against the Vegas Golden Knights, Sunday, Feb. 1, 2026, in Anaheim, Calif. (AP Photo/Mark J. Terrill) Anaheim Ducks defenseman Radko Gudas, left, falls after hip checking Vegas Golden Knights right wing Jonas Rondbjerg during the second period of an NHL hockey game Sunday, Feb. 1, 2026, in Anaheim, Calif. (AP Photo/Mark J. Terrill) Vegas Golden Knights defenseman Shea Theodore, left, moves the puck while under pressure from Anaheim Ducks left wing Alex Killorn during the first period of an NHL hockey game Sunday, Feb. 1, 2026, in Anaheim, Calif. (AP Photo/Mark J. Terrill)

Golden Knights Ducks Hockey

Cutter Gauthier scored and Ryan Poehling added an empty-net goal for the Ducks. Anaheim earned its eighth victory in 10 games overall despite nearly blowing an early 3-0 lead during a third period dominated by Vegas.

Mitch Marner and Ivan Barbashev scored goals in their third straight games for the Golden Knights, who have lost five straight and seven of eight. Vegas has gone on two five-game skids since Christmas, with an 8-2-0 surge sandwiched between them.

Tomas Hertl scored with 6 seconds to play and Adin Hill stopped 19 shots for Vegas.

Kreider put Anaheim up 2-0 with his first multigoal game since Nov. 6 for the Ducks, who acquired him last June from the New York Rangers.

He opened the scoring late in the first when a puck from Poehling hit his leg and went in. He tipped home his 19th goal early in the second.

Gauthier scored his 24th goal a few minutes later, beating Hill at the near post for Anaheim's fifth power-play goal in five games.

Marner took advantage of a lucky deflection when Mark Stone's pass from behind the net ricocheted off two Ducks and went straight to him.

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Vegas took control in the third period, and Barbashev tapped home a stationary puck in the crease after Dostal couldn't smother Jack Eichel's shot.

Anaheim right wing Troy Terry returned from an 11-game absence with an upper-body injury, and center Mason McTavish also returned after missing five games.

The Ducks had their eighth consecutive sellout as they returned from a five-game road trip to begin a nine-game homestand. Anaheim doesn't play another road game until March 10.

Golden Knights: Host Vancouver on Wednesday.

Ducks: Host Seattle on Tuesday.

AP NHL:https://apnews.com/NHL

Chris Kreider scores 2 goals, Ducks beat slumping Golden Knights 4-3 to sweep season series

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